The Osteoporosis Education Project
The Osteoporosis Education Project (OEP) is a non-profit, public interest research and education organization. Its mission is to explore the human potential for bone health maintenance and
regeneration, seeking natural ways to build and rebuild bone. As a part of our public interest work OEP studies
and attempts to document the efficacy of natural bone building products and formulations.
As the Director of The Osteoporosis Education Project I have had the opportunity to experiment widely with
natural bone- building programs. Unfortunately, I have learned that it is often difficult to halt bone loss, much
less rebuild bone, with simple natural means. Given our experience, we are constantly looking for new natural
formulations, which report success in halting and even beginning to reverse osteoporosis.
Some five years ago the product known as OsteOrganiCAL was brought to my attention. Over the years I have
been presented with dozens of “before and after” bone density measurements which suggest the product is
indeed capable of halting bone loss and even rebuilding a significant amount of bone. Intrigued by these results
I agreed to review a series of OsteOrganiCAL cases, checking to validate their accuracy. The following is a report
on our analysis of these OsteOrganiCAL cases.
OsteOrganiCAL Case Study Analysis Introduction
Over the past eleven years the Natural Option Corporation of Coral Gables, Florida has been selling direct-to the-
public a novel sea algae calcium compound packaged with a natural Vitamin D from shark oil. The product, known as OsteOrganiCAL, is assayed to contain calcium 340 mg; magnesium 32 mg; iron 0.31 mg;
manganese .07 mg; Vitamin D3 800 IU; and Vitamin A 70 IU (per 2 caps of the calcium compound and 1 cap of
the Vitamin D3 compound). The product is purported to halt bone loss and to build bone. The manufacturer,
in fact, has been so confident in the product that they have long offered a money back guarantee. Should a user
document that they did not experience a bone building effect, the money they invested in this product is
returned. Reportedly, per each 1,000 sales only twenty-five individuals request their money back, and 90% of
these requests come within 30 days of purchase.
On the other hand, over the years many individuals have voluntarily sent the Natural Option Corporation
sequential bone mineral density measurements documenting the increases in bone mineral they experienced
while using OsteOrganiCAL. For the purpose of this research ten such volunteered cases of apparent successful bone
building from OsteOrganiCAL were sent to me for my review.
Case Study Series Analysis
Number of Cases Analyzed: 10 cases of postmenopausal women with excessive bone loss were analyzed.
Type of Sample: This sample of ten cases involves what is known as an “availability” sample. The Natural Option
Corporation made known their interest in seeing recent before and after bone mineral testing and offered
individuals an opportunity to participate in a review of their case to be conducted by myself. Those individuals
who most readily responded to this offer were those included in this case study analysis.
Analysis Protocol: First we analyzed and documented the bone mineral density reports from before and after the
use of OsteOrganiCAL. Second, she conducted telephone interviews with each of these women. Lastly the
data was complied and the report written.
Research Findings: It is very clear from careful analysis of these ten cases that OsteOrganiCAL had a bone building
effect on these women. In seven cases OsteOrganiCAL was the only substance used, while all other variables
remained nearly constant. In these cases there is no doubt that the bone building effect documented was derived
from OsteOrganiCAL use.
In one case (Case 8) OsteOrganiCAL was the new component of a long established drug treatment bone program.
In the two other cases (Cases 9 and 10) the women also experienced good bone mineral increases. However, I
cannot guarantee that these gains were solely due to OsteOrganiCAL, as these two women were also taking another
substance that could have had a bone building effect. I have included these cases for completeness. Further, these
case studies strongly suggest that there might be an important role for OsteOrganiCAL when used in conjunction
with other bone therapies. As it appears, the use of OsteOrganiCAL in conjunction with anti-resorptive drug therapy
leads to unprecedented gains in bone mineral density.
Case # 1 — Doris Falk, Little Falls, MN, Age 72, Dx: Osteoporosis of Spine and Hip
Doris has had five sequential bone density measurements since 1996. These measurements
documented that she was consistently losing bone. She began using OsteOrganiCAL in the 2 calcium caps
and 1 vitamin D cap recommended dose (from here on to be called the “recommended dose”).
Doris began OsteOrganiCAL in 4-2001 and after 14 months using the product she had gained bone mineral
density at all sites tested (+1.7% in the total hip; +2.6 in the femoral neck and + 1.8% in the spine).
Case # 2 — Rose Teeters, La Ponte, IN, Age 87, Dx: Osteoporosis Hip and Spine
Rose began OsteOrganiCAL 10-2000, with a baseline bone density test of 11-2000. During this period she
used the recommended dose of the product. After 12 months using OsteOrganiCAL she increased bone
mineral density in both the spine and hip (+ 7.8% spine and +2.3% hip). Scoliosis may influence
spinal reading.
Case # 3 — Paulina Thoma, IL, Age 92, Dx: Osteoporosis(Subject requested that city not be listed)
Paulina is a nursing home resident who had a CT Scan 2-2000 providing a diagnosis of spinal
osteoporosis (only the spine was measured). She began OsteOrganiCAL in the recommended dose in
4-2001. Paulina took no other bone-building agents. The bone density improvement between her
tests of 5-2001 and 10-2001while on OsteOrganiCAL moved her from having severe osteoporosis with a
–3.5 standard deviation score in early 5-2001, to a just barely having the osteoporosis diagnosis of
–2.5 standard deviations six months later in late 10-01.
Case # 4 — Elizabeth Wilding, Ramsey, NJ, Age 87, Dx: Osteoporosis of Hip and Osteopenia of
Spine
Elizabeth had a bone density measurement in 9-99 which indicated osteoporosis of the hip and
spine. She began using OsteOrganiCAL 11-99 and continued thereafter while using no other
medication that would impact bone. The follow-up bone density test done 18 months later in 5-01
showed an increase of total hip bone mineral of +2.5; a spinal increase of +18.9 and a wrist decrease
of –5.3%. She took the recommended dose of OsteOrganiCAL
Case #5 — Lois Ghan, Ione, CA, Age 71, Dx. Osteoporosis of Wrist (distal radius)
Lois was diagnosed with osteoporosis by a single measurement of the distal radius (wrist) in 8-02.
She was on no other bone medications and began OsteOrganiCAL in the recommended dose in late 9-
2001. A bone density of late 8-2001 serves as her baseline measurement. Between 8-2001 and 7-
2002 while on OsteOrganiCAL she gained 4.5% in the distal radius.
Case # 6 — Janice Green, Houston, TX, Age 54, Dx: Osteopenia of Spine
Janice was diagnosed with osteopenia of the spine and found to have hip bone density lower than
that of the average young person (but not yet in the osteopenia range). In 1-2001 she began
OsteOrganiCAL because her mother had severe osteoporosis and Janice feared losing bone. Janice
took the recommended dose. She was on no other medications that would impact bone. Although
only having mild osteopenia, Janice experienced a spinal increase of 4.8% and a 0.1% increase in
the total hip during the time she was on OsteOrganiCAL (1-25-01 to 4-13-02). She, as the other
women studied, continues on this product today.
Case # 7 — Marlene Buras, Kenner, LA, Age 67, Dx: Osteoporosis of the hip; normal spine density
In 4-2000 Marlene was diagnosed with osteoporosis in the hip. Her next bone density in 8-2001
showed on-going bone loss of both the spine and hip. In 8-2001 she began using OsteOrganiCAL in the
recommended dose. Between 8-2001 and 3-2002 she gained 3.7% in the spine and 0.6% in the hip.
Case # 8 — Ruth Wright, Greeley, CO, Age 82, Dx: Osteoporosis of Hip, Osteopenia of Spine
Ruth has been using anti-resorptive drug therapy since 1995 without a baseline bone density
measurement. Her “baseline” test was 4-99 having already been on anti-resorptive drug therapy for
some four years. Ruth began using the recommended dose of OsteOrganiCAL in 2-2000 while
continuing on the anti-resorptive drug therapy. Her subsequent bone density tests from 4-2000 to 4-
2002 showed increases that in my analysis are clearly due to the addition of OsteOrganiCAL. I suggest
this because Ruth had been on anti-resorptive drug therapy for over four years when she began
OsteOrganiCAL. At that point the bone building impact of anti-resorptive drug therapy should have
reached a plateau and subsequent large changes in bone mineral would not be expected. The
increases in bone mineral seen when OsteOrganiCAL was added to the long established anti-resorptive
drug therapy program were +5.9% in the spine and +11.6% in the hip. She had been on
OsteOrganiCAL 22 months at the time of this follow-up bone mineral test.
Case #9 — Marion Williams, Pilesgrove, NJ, Age 68, Dx: Osteopenia of the Spine
Marion had a bone mineral measurement on 11-6-2000 with a diagnosis of osteopenia of the spine.
She began taking OsteOrganiCAL in 12-2000. Between 11-2000 and 5-200l, while on the recommended
dose of OsteOrganiCAL, Marion showed a spinal increase of 3.2% and a hip increase of 1.3%.
Interestingly enough, before using this product she experienced a 3.57% loss in spinal bone mineral
from 10-99 to 11-2000. Marion’s case might be confounded, however, because during 6 months of her
time using OsteOrganiCAL she also used some amount of soy isoflavones. As best she recalls, during 6
months of OsteOrganiCAL use she also used some 80 mgs of soy isoflavones from four to five times a
week. From my research on soy isoflavones, I do not believe this dose of soy isoflavones had a
significant bone building effect. This possibility, however, cannot totally be ruled out. Soy isoflavone
research suggests that regular daily use of 100 mgs of soy isoflavones is needed to obtain a much less
modest increase in bone density. Marion was only taking 80 mg of the isoflavone on an irregular basis.
Case #10 — Irene Mields, Alexandria, VA, Age 77, Dx: Osteopenia of Hip and Spine
Irene was diagnosed with osteopenia in June, 1999 and began use of anti-resorptive drug therapy. Ten
months later she began OsteOrganiCAL, taking it along with the anti-resorptive drug therapy she had
already been on for ten months. In August, 2001 she obtained a follow-up bone mineral test (being on
OsteOrganiCAL nearly 15 months and on anti-resorptive drug therapy some 26 months at this time).
Between the bone mineral tests of 6-99 and 8-2001 she was documented to gain 7.5% spinal bone
mineral and 18.4% hip density. As the radiologist technician commented to her, these gains are very
unusual and not commonly (if ever) seen with the use of anti-resorptive drug therapy alone. These
exceptional gains in bone mineral obtained by combining the drug anti-resorptive drug therapy with
OsteOrganiCAL suggest a new possibility of combined therapies well worth investigating.
Study Conclusion
While retrospective case studies of this sort by their nature lack a refined scientific rigor, analysis of these cases
documents the potential of this novel calcium and Vitamin D product to halt and reverse the osteoporosis
process in postmenopausal women.
The bone mineral gains attributable solely to the use of OsteOrganiCAL were as high as 18%. Younger
postmenopausal women in their fifth and sixth-decade benefited, as well as older women in their seventh decade
and beyond. In most cases greater gains were seen in the spine than in the hip. Also, osteoporosis research
suggests that those with the most bone loss benefit the most from nutrient therapy. Using OsteOrganiCAL however,
the few women in the sample with only moderate bone loss (osteopenia) also benefited significantly from this
therapy. Finally, the three cases in which OsteOrganiCAL was used in conjunction with another bone-enhancing
therapy suggest that combining OsteOrganiCAL with other therapies might lead to unusually large gains in bone
mineral density.
The Next Step in OsteOrganiCAL Research
In this analysis all of the women studied gained bone mineral density while using OsteOrganiCAL. And indeed, all
of the women interviewed were pleased with their progress and continued on the product. The next question is,
just how representative is this sample? That is, just how many postmenopausal women would gain bone density
if given OsteOrganiCAL?
To answer this question The Osteoporosis Education Project has joined with the Natural Option Corporation to
conduct a clinical trial assessing the ability of OsteOrganiCAL to reduce bone resorption in the short term (three
months) and to halt osteoporosis and rebuild bone in the longer term (one year). This study, known as the
“OsteOrganiCAL One Year Clinical Trial” |
